A new cellular mechanism for coupling inputs arriving at different cortical layers.Häusser, M., Major, G. & Stuart, G.J. and J.S.

& Schiller, Y. NMDA spikes in basal dendrites of cortical pyramidal neurons.Polsky, A., Mel, B.W. Here we report the existence of dendritic spikes in apical oblique dendrites of L5PNs.The authors have declared no competing interest.Thank you for your interest in spreading the word about bioRxiv.NOTE: Your email address is requested solely to identify you as the sender of this article.The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.Enter multiple addresses on separate lines or separate them with commas.This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.Dendritic spikes in apical oblique dendrites of cortical layer 5 pyramidal neurons,John Curtin School of Medical Research, Australian National University,Research School of Physics, Australian National University,Australian Research Council Centre of Excellence for Integrative Brain Function, Australian National University.All rights reserved. The most complex cerebral functions are performed by the cortex which most important output is carried out by its layer 5 pyramidal neurons. The GABA(B1b) Isoform Mediates Long-Lasting Inhibition of Dendritic Ca,Larkum, M.E.

Action potentials in basal and oblique dendrites of rat neocortical pyramidal neurons.Milojkovic, B.A., Radojicic, M.S., Goldman-Rakic, P.S. performed the computer simulations.The authors declare no competing financial interests.The effect of dendritic depolarization on BAP propagation to basal dendrites. Spike timing-dependent plasticity: from synapse to perception.Larkum, M.E., Zhu, J.J. & Sakmann, B.

There is evidence that astrocytes influence cortical neurons firing through the release of gliotransmitters such as ATP, glutamate or GABA. Signaling of layer 1 and whisker-evoked Ca.Milojkovic, B.A., Radojicic, M.S. & Häusser, M. A cooperative switch determines the sign of synaptic plasticity in distal dendrites of neocortical pyramidal neurons.Rhodes, P. The properties and implications of NMDA spikes in neocortical pyramidal cells.Gasparini, S., Migliore, M. & Magee, J.C. On the initiation and propagation of dendritic spikes in CA1 pyramidal neurons.Rathenberg, J., Nevian, T. & Witzemann, V. High-efficiency transfection of individual neurons using modified electrophysiology techniques.Destexhe, A., Mainen, Z.F.
We repeatedly imaged the same dendrites in young adult and aged mouse motor cortex over the course of 1 month to look for differences in the baseline state of the dendritic spine population.

To achieve fast and reversible inactivation of L2/3 pyramidal neurons, we transfected them with the light-sensitive proton pump archaerhodopsin (ArchT-GFP) (Han et al., 2011). & Magee, J.C. Integrative properties of radial oblique dendrites in hippocampal CA1 pyramidal neurons.Kampa, B., Letzkus, J.J. & Stuart, G. Requirement of dendritic calcium spikes for induction of spike-timing dependent synaptic plasticity.Wimmer, V.C., Nevian, T. & Kuner, T. Targeted.Dan, Y. ).Thomas Nevian and Matthew E Larkum: These authors contributed equally to this work.Department of Physiology, University of Berne, Bühlplatz 5, Berne, 3012, Switzerland,Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg, 69120, Germany,Department of Physiology, Technion Medical School, Bat-Galim, Haifa, 31096, Israel.T.N., M.E.L. Layer III, the external pyramidal layer, contains predominantly small and medium-size pyramidal neurons, as well as non-pyramidal neurons with vertically oriented intracortical axons; layers I through III are the main target of interhemispheric corticocortical afferents, and layer III is the principal source of corticocortical efferents. A.P. If you originally registered with a username please use that to sign in.To purchase short term access, please sign in to your Oxford Academic account above.Don't already have an Oxford Academic account?Oxford University Press is a department of the University of Oxford.

& Antic, S.D. These experiments reveal increased dendritic spine density, without obvious changes in spine clustering, occurring at the aged dendrite.

Dependence of EPSP efficacy on synapse location in neocortical pyramidal neurons.Berger, T., Larkum, M.E.

Apical tuft input efficacy in layer 5 pyramidal cells from rat visual cortex.Schiller, J., Schiller, Y., Stuart, G. & Sakmann, B. Calcium action potentials restricted to distal apical dendrites of rat neocortical pyramidal neurons.Larkum, M.E., Kaiser, K.M.
& Poo, M.M. Larkum et al. & Sakmann, B.

High I-h channel density in the distal apical dendrite of layer V pyramidal cells increases bidirectional attenuation of EPSPs.Zhu, J.J. Maturation of layer 5 neocortical pyramidal neurons: amplifying salient layer 1 and layer 4 inputs by Ca.Lörincz, A., Notomi, T., Tamás, G., Shigemoto, R. & Nusser, Z. Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites.Jaffe, D.B.