strontium citrate pros and cons

This is more important for postmenopausal women. View abstract. PROOF Study Group. View abstract. A., Preston, D. F., Wegst, A. V., and Martin, N. L. Treatment of metastatic bone pain with strontium-89. Meunier, P. J., Roux, C., Ortolani, S., Diaz-Curiel, M., Compston, J., Marquis, P., Cormier, C., Isaia, G., Badurski, J., Wark, J. D., Collette, J., and Reginster, J. Y. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group. View abstract. Strontium ranelate acts through dual mechanisms of inhibiting resorption by osteoclasts and maintaining or stimulating bone formation by osteoblasts. Kishore A, Mehrotra KK, Saimbi CS. J Periodontol 1987;58:470-4. A prospective, multicenter, three-month, randomized, double-blind, placebo-controlled trial. Low . Osteoporos Int. View abstract. Some tetracycline antibiotics include demeclocycline (Declomycin), minocycline (Minocin), and tetracycline. 2006;3:CD005326. Liu, J. M., Wai-Chee, Kung A., Pheng, C. S., Zhu, H. M., Zhang, Z. L., Wu, Y. Y., Xu, L., Meng, X. W., Huang, M. L., Chung, L. P., Hussain, N. H., Sufian, S. S., and Chen, J. L. Efficacy and safety of 2 g/day of strontium ranelate in Asian women with postmenopausal osteoporosis. View abstract. Dijkgraaf-Ten Bolscher M, Netelenbos JC, Barto R, van der Vijgh WJ. 1990;34(3):545-560. I will be contacting my urologist who I just began working with to let her know about Strontium. Strontium Citrate side effects - Osteoporosis - Inspire Ringe, J. D. and Doherty, J. G. Absolute risk reduction in osteoporosis: assessing treatment efficacy by number needed to treat. J Biol Chem 1972;247:5520-6. View abstract. N.Engl.J.Med. According to the Michigan Health website: Compared with children with fewer cavities, enamel samples from children with high numbers of caries have been found to contain significantly less strontium. The product can increase bone density, and it can also slow down bone loss. The typical diet includes 0.5 to 1.5 milligrams of strontium each day. JAMA 12-23-1998;280(24):2077-2082. Les Laboratoires Servier ceased the distribution of Protelos/Osseor in August 2017. View abstract. [RETRACTED]. Get answers to some of the most common questions about osteoporosis treatment. View abstract. J Rheumatol 2000;27:205-11. View abstract. 2009;41(7):559-562. 2002;13(12):925-931. In general, there is not enough research to determine if any form of Sr is safe for pregnant and nursing moms so its best not to use these supplements under these circumstances. View abstract. A generic, non-branded version of strontium ranelate, from Aristo Pharma Ltd., is still available in the U.K.[2] with a number of special warnings and precautions for its use. Scand J Rheumatol 2001;30(4):242-247. Dose-dependent effects of strontium on osteoblast function and mineralization. 1986;12(9):447-454. This could cause the body to have too much strontium and potentially cause side effects. Bone 2009;45(6):1059-1064. Does anyone take Forteo ? Black, D. M., Cummings, S. R., Karpf, D. B., Cauley, J. Zinner, D. D., Duany, L. F., and Lutz, H. J. Overall, the results of this 2013 study performed with male subjects demonstrated that strontium ranelate supplementation appears to improve bone mineral density in men similar to the way it has been shown to help postmenopausal women struggling with osteoporosis. Theres not enough research to know if strontium fights osteoporosis. Zinc: Benefits, intake, sources, deficiency, and side effects Available at: www.emea.eu.int/humandocs/Humans/EPAR/protelos/protelos.htm. FreshSplash/Getty Images. 1996;67(8):737-742. A meta-analysis of chondroitin sulfate in the treatment of osteoarthritis. Afflitto, J., Schmid, R., Esposito, A., Toddywala, R., and Gaffar, A. Fluoride availability in human saliva after dentifrice use: correlation with anticaries effects in rats. Biol.Trace Elem.Res. 2000;11(1):83-91. Nonvertebral fracture benefit from oral ibandronate administered daily or with a unique drug-free interval: Results from a pivotal phase III study in postmenopausal osteoporosis (PMO). 1994;65(2):113-119. View abstract. Incorporation and distribution of strontium in bone. Do not take it within 2 hours of ingesting calcium so I take it at bedtime. 2010;30(7):863-869. 2012. View abstract. Reginster, J. Y., Bruyere, O., Sawicki, A., Roces-Varela, A., Fardellone, P., Roberts, A., and Devogelaer, J. P. Long-term treatment of postmenopausal osteoporosis with strontium ranelate: results at 8 years. 2012;23(1):295-303. doi: 10.1007/s00198-011-1547-8. El-Hajj Fuleihan G. Strontium ranelate--a novel therapy for osteoporosis or a permutation of the same? J.Periodontol. Go to the Bones, Joints & Muscles Support Group. Pelletier JP, Roubille C, Raynauld JP, et al. and I don't hear much about it. Proc.R.Soc.Lond B Biol.Sci. It is prescribed only for those who would otherwise have no other suitable treatment to reduce their risk of broken bones.[2]. View abstract. If side effects are persistent or worsen, it is best to talk to your healthcare provider. Consensus-based recommendations for the diagnosis and management of dentin hypersensitivity. 2007;5(4):692-699. What Is Relationship Between Strontium Citrate and Hair Loss? - NutriAvenue 2000;57(3):1107-1114. One scientific review published in 2014 by a doctor with admitted ties to pharmaceutical makers concludes, The increased risk for cardiac events with strontium ranelate has been detected in randomized clinical trials but not in real-life observational studies. (9), Ultimately, the European Union now only endorses the use of strontium ranelate in severe cases of osteoporosis with high fracture risk. . (24, 25). You are lucky to still be able to get some control over this. 2007;19(4):330-333. Clin.Prev.Dent. Periodontics. Can Med Assoc J 1981;125:703-12.. View abstract. Aging Clin.Exp.Res. My bone density has shown some improvement and no further decline. Les Laboratoires Servier, 2006. Please note the date of the last review on all articles. Strontium ranelate is comprised of 27.8% strontium and 72.2% ranelic acid. Strontium can attach to some antibiotics called quinolones in the stomach. Esomeprazole (Nexium) is not the same medication as esomeprazole strontium, although both are used to treat similar stomach conditions. Protelos European Summary of Product Characteristics. 2006;21(4):536-542. 2010;21(2):49-55. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. View abstract. Effectiveness of desensitizing agents. Currently, we do not have a way to measure the false increase in bone density that results when you take a supplement or a medication that includes strontium.. In Australia and some countries in Europe, a form of strontium called strontium ranelate (Osseor Protelos) is available as a prescription medication to treat and prevent osteoporosis and bone fractures. The effect of prior bisphosphonate therapy on the subsequent therapeutic effects of strontium ranelate over 2 years. N.Engl.J.Med. Strontium Boost is supposed to have no side effects at all. If youre not into chemistry, then those scientific facts probably dont mean that much to you. View abstract. Today we will talk to our Cleveland Clinic experts regarding steps you can take to prevent this disease and treatments that may be needed. View abstract. (13). 5-10-2001;344(19):1434-1441. View abstract. I wont name names, but some of the most well-known toothpastes for sensitive teeth include strontium in their formulas. Bone 2006;38(2 Suppl 1):23-27. Kidney Int 2003;64:534-43. . Manicourt, D. H., Azria, M., Mindeholm, L., Thonar, E. J., and Devogelaer, J. P. Oral salmon calcitonin reduces Lequesne's algofunctional index scores and decreases urinary and serum levels of biomarkers of joint metabolism in knee osteoarthritis. I just read this article about strontium. Center for drug evaluation and research. J.Thromb.Haemost. Omdahl JL, DeLuca HF. That means it may affect how strong your bones are. Ann Rheum Dis. The effect of fluoride and strontium application on dentin: in vivo and in vitro studies. 2010;46(4):1038-1042. doi: 10.1016/j.bone.2009.12.006. In 2013, the committee of the European Medicines Agency (similar to the FDA in the United States) recommended suspending strontium ranelate (brand name Protelos/Osseor) for treating osteoporosis. 7-27-1965;162(989):458-472. 2017 Aug;55(8):93-94. 2002;17(3):449-454. Research from Europe suggests that patients on strontium ranelate may have an increased risk of heart attacks. This article is based on scientific evidence, written by experts and fact checked by our trained editorial staff. J.Clin.Dent. (Strontium may remain in the bones for as long as 710 years after the last dose.) "Hello @bonelady. 99% of the strontium found in the human body is in the bone. Upset stomach and diarrhea are the most common side effects of magnesium oxide. 2000;75(1-3):253-263. Hip Intervention Program Study Group. Strontium ranelate increases cartilage matrix formation. 2011;22(8):2347-2355. It is also shown to positively impact the body's usage of testosterone, estrogen, and vitamin D. Oncology 1998;55:377-81. (1) A radioactive form is even used as a form of cancer treatment for bone cancers andprostate cancer. Many consumers are being lured by the advertised benefits of strontium for bone health. Cochrane Database Syst Rev 2006;(4):CD005326. 2004;19(8):1241-1249. Oosterhof GO, Roberts JT, de Reijke TM, et al. Dermatology 2000;200(3):244-246. The application of Sr-89 is cost-effective, especially when compared with [opioid painkillers]. View abstract. View abstract. Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis--a 2-year randomized placebo controlled trial. (14). Strontium may also influence other essential functions, including calcium absorption, bone formation & breakdown, and it restores alkaline pH to improve the health of skin, hair, and nails). 2013 Feb;98(2):592-601. doi: 10.1210/jc.2012-3048. Clinically meaningful effect of strontium ranelate on symptoms in knee osteoarthritis: a responder analysis. Feeling slightly more pain in the areas of cancer in your bones for a few days. Note that the numbers in parentheses (1, 2, etc.) View abstract. Available at: www.servier.com/pro/osteoporose/protelos/protelos_spc.asp. If you want to take a strontium supplement, ask your doctor first. Calcium citrate has an acidic base, so it doesn't require hydrochloric acid for absorption. Lyles, K. W., Colon-Emeric, C. S., Magaziner, J. S., Adachi, J. D., Pieper, C. F., Mautalen, C., Hyldstrup, L., Recknor, C., Nordsletten, L., Moore, K. A., Lavecchia, C., Zhang, J., Mesenbrink, P., Hodgson, P. K., Abrams, K., Orloff, J. J., Horowitz, Z., Eriksen, E. F., and Boonen, S. Zoledronic Acid in Reducing Clinical Fracture and Mortality after Hip Fracture. 1978;49(5):269-272. Fidelix, T. S., Soares, B. G., and Trevisani, V. F. Diacerein for osteoarthritis. Membership to ConsumerLab.com is available online and provides immediate access to reviews of more than 1,000 products from over 400 brands. Methods: Custom-made MDO devices were placed on 20 New Zealand White rabbits. Dermatol.Surg. It can be found in soil and seawater as well as some foods. I now take 680 mg strontium citrate without side effects and the fractures have stopped. No tummy upset this time, have been increasing very slowly as I am very med sensitive, so was on 40mg for 10 days and now 40mg one day and 80 mg every second day for a week, but the tiredness is difficult to put up with. 4-12-2005;172(8):1039-1043. 2007;18(12):1617-1624. Kanapka, J. This article will be helpful to you if you experience joint discomfort, especially from rheumatoid arthritis and other joint health disorders. https://www.mayoclinic.org/diseases-conditions/osteoporosis/in-depth/osteoporosis-treatment/art-20046869, https://connect.mayoclinic.org/discussion/reclast-infusion/, https://americanbonehealth.org/bonesense/why-strontium-is-not-good-for-bone-health/. WebMD does not provide medical advice, diagnosis or treatment. Hello @bonelady welcome to Connect. Spector, T. D., Conaghan, P. G., Buckland-Wright, J. C., Garnero, P., Cline, G. A., Beary, J. F., Valent, D. J., and Meyer, J. M. Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]. Maheu E, Mazieres B, Valat JP, et al. Male hormones (Androgens) might decrease how fast the body gets rid of strontium. Anastasilakis, A. D., Polyzos, S. A., Avramidis, A., Papatheodorou, A., and Terpos, E. Effect of strontium ranelate on lumbar spine bone mineral density in women with established osteoporosis previously treated with teriparatide. Ann Intern Med 2007;146:580-90. Some research shows that giving a special prescription form of strontium (strontium-89 chloride) intravenously (by IV) slows the growth of prostate cancer that is resistant to treatment and also relieves pain. A typical dosage of strontium in over-the-counter supplements is 680 mg a day. Select a condition to view a list of vitamins. 11 possible benefits. Harris, S. T., Watts, N. B., Genant, H. K., McKeever, C. D., Hangartner, T., Keller, M., Chesnut, C. H., III, Brown, J., Eriksen, E. F., Hoseyni, M. S., Axelrod, D. W., and Miller, P. D. Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Some research says that women with osteoporosis may not absorb strontium as they should. The naturally occurring form is made up of four stable isotopes: Sr-88 (82.6 percent), Sr-86 (9.9 percent), Sr-87 (7.0 percent), and Sr-84 (0.56 percent). I was diagnosed with osteopenia", "I have osteoporosis and am afraid of the treatments for it have been trying strontium citrate", "My wife has severe Osteoporosis .It has been improving with Medicines, Yearly injections , Exercise ,". Selective Estrogen Receptor Modulators (SERMs), Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Smoking Pot Every Day Linked to Heart Risks, Artificial Sweetener Linked to Heart Risks, FDA Authorizes First At-Home Test for COVID and Flu, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Bone Mineral Density Test: What to Expect, Newer Osteoporosis Treatments Build Stronger Bones, Breakfasts for Strong Bones: 12 Foods to Boost Bone Health, Cant move very much, either for a short time, such as after surgery, or for the long term, such as because of a disability. Obtaining strontium from your diet by eating seafood, whole grains,beans, spinach, lettuce, celery, androot vegetableslike carrots and potatoes is the safest way to boost your strontium levels. Tofu, firm, made with calcium sulfate, cup 253 mg per serving. This technology we use to assemble our list depends on a variety of factors, including but not limited to the following: Brand Value: Every brand of strontium citrate . Gedalia, I., Brayer, L., Kalter, N., Richter, M., and Stabholz, A. Bone. View abstract. Oger, E. Incidence of venous thromboembolism: a community-based study in Western France. Kanis, J. Groupe d'Etude de la Thrombose de Bretagne Occidentale. Spets-Happonen, S., Seppa, L., Korhonen, A., and Alakuijala, P. Accumulation of strontium and fluoride in approximal dental plaque and changes in plaque microflora after rinsing with chlorhexidine-fluoride-strontium solution. 3-23-1998;158(6):585-593. The most common supplement form is strontium citrate. The PRAC weighed the benefits of the medicine against the known risks and concluded that the balance was no longer favourable and recommended Protelos/Osseor be suspended until there are new data showing a favourable balance in a defined patient group.[1]. View abstract. Faith123 may", "Hello @bonelady -- welcome to Connect. 1992;23(10):705-711. Reginster, J. Y., Seeman, E., De Vernejoul, M. C., Adami, S., Compston, J., Phenekos, C., Devogelaer, J. P., Curiel, M. D., Sawicki, A., Goemaere, S., Sorensen, O. H., Felsenberg, D., and Meunier, P. J. Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study. Its not an idea that is super-new either. Roux, C., Reginster, J. Y., Fechtenbaum, J., Kolta, S., Sawicki, A., Tulassay, Z., Luisetto, G., Padrino, J. M., Doyle, D., Prince, R., Fardellone, P., Sorensen, O. H., and Meunier, P. J. Vertebral fracture risk reduction with strontium ranelate in women with postmenopausal osteoporosis is independent of baseline risk factors. Robinson, R. G., Spicer, J. It may even cause constipation or digestive discomfort. 1990;1(1):19-23. Aluminum, iron, lead, cadmium, copper, zinc, chromium, magnesium, strontium, and calcium content in bone of end-stage renal failure patients. Some quinolone antibiotics include ciprofloxacin (Cipro), gemifloxacin (Factive), levofloxacin, moxifloxacin (Avelox), and others. Blitzer, B. @faith123, recently posted about having a second reclast infusion recently here, https://connect.mayoclinic.org/discussion/reclast-infusion/. View abstract. An extensive scientific review published in 2000 concludes that: It is clear from published reports and from daily practice that injection with Sr-89 is a simple, well-tolerated treatment providing a considerable chance of good palliation of pain in patients with bone metastases from prostate cancer. Interaction of strontium and vitamin D. C R Seances Soc Biol Fil 1975;169:322-9. Arthritis Rheum. Vlad, S. C., LaValley, M. P., McAlindon, T. E., and Felson, D. T. Glucosamine for pain in osteoarthritis: why do trial results differ? A common therapeutic dose you will often seen recommended for boosting bone health is 680 milligrams per day. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. View abstract. It's also known to increase osteoprotegerin that serves as the decoy for the RANKL and slows the rate of bone resorption. A., Cosman, F., Lakatos, P., Leung, P. C., Man, Z., Mautalen, C., Mesenbrink, P., Hu, H., Caminis, J., Tong, K., Rosario-Jansen, T., Krasnow, J., Hue, T. F., Sellmeyer, D., Eriksen, E. F., and Cummings, S. R. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. Arch.Intern.Med. Appelboom, T., Schuermans, J., Verbruggen, G., Henrotin, Y., and Reginster, J. Y. Some years later in 1808, it was was isolated in its metallic formusing electrolysisby Sir Humphry Davy at the Royal Institution in London. Next year will be my third year off the reclast so it will be interesting to see what docs will then suggest. Oral Dis. View abstract. Hernandez, F., Mohammed, C., Shannon, I., Volpe, A., and King, W. Clinical study evaluating the desensitizing effect and duration of two commercially available dentifrices. What supplements help Osteopenia, Osteoporosis? - Mayo Clinic Connect Johnson, G. H., Bales, D. J., Gordon, G. E., and Powell, L. V. Clinical performance of posterior composite resin restorations. Seeman, E., Vellas, B., Benhamou, C., Aquino, J. P., Semler, J., Kaufman, J. M., Hoszowski, K., Varela, A. R., Fiore, C., Brixen, K., Reginster, J. Y., and Boonen, S. Strontium ranelate reduces the risk of vertebral and nonvertebral fractures in women eighty years of age and older. Accessed May 1, 2018. More Information In your diet, you get it mainly from seafood, but you can also get small amounts of it in whole milk, wheat bran, meat, poultry, and root vegetables. View abstract. You also do not know whether they can seriously harm you. Hunter House, 2014. View abstract. 2007;357:nihpa40967. Effects of strontium ranelate on spinal osteoarthritis progression. However, there has also been concern over strontium ranelates effects on heart health. 2008;39(4):321-325. View abstract. EPI-GETBP Study Group. Efficacy and safety of strontium ranelate in the treatment of osteoporosis in men. Sr should be used with caution for those with kidney disease and if you have advanced kidney disease, then strontium ranelate is not recommended at all. 2003;14 Suppl 3:S56-S65. FDA. J.Periodontol. Diagnosis and Management. 2006;(2):CD005321. Malaise, O., Bruyere, O., and Reginster, J. Y. Strontium ranelate normalizes bone mineral density in osteopenic patients. View abstract. It is said to have first been found in the ores of lead mines in Strontian in 1787. N Engl J Med 2004;350:459-68.. View abstract. My Dr wants me to start taking this. Middleton ET, Steel SA, Aye M, Doherty SM. A., Mohr, D. N., Petterson, T. M., O'Fallon, W. M., and Melton, L. J., III. Thromb.Haemost. Acta Derm Venereol. What Are Your Osteoporosis Medication Options? - HealthCentral View abstract. Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system. View abstract. A comparative clinical study investigating the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride in a silica base and a control dentifrice containing 1450 ppm fluoride in a silica base to provide immediate relief of dentin hypersensitivity. Cochrane Musculoskeletal Group. Also, the FDA doesnt regulate supplements in the same way as prescription drugs, so it's not possible to know if if they are safe or work well or even how much of the main ingredient they contain. View abstract. This is not the same as making new bone. What else is it good for? The effect of a strontiumhloridetoothpaste on root hypersensitivity in a controlled clinical study. Most people who take strontium citrate report their fractures STOP. [1] PRAC recommends suspending use of Protelos/Osseor. 2014. J Endod 2002;28:34-5. Kidney Int 1999;56:1886-92. Ann Rheum Dis. A comparison of the palliative effects of strontium-89 and external beam radiotherapy in metastatic prostate cancer. Small doses of strontium citrate are generally safe and effective, but some sensible precautions apply. Mayo docs say it will stay in my system for up to three years. Peng H, Yao F, Xiong S, Wu Z, Niu G, Lu T. Strontium in public drinking water and associated public health risks in Chinese cities. Black, D. M., Delmas, P. D., Eastell, R., Reid, I. R., Boonen, S., Cauley, J. Is Lamb Healthy? Ter.Arkh. In the mean time I do have bone density scans to keep an eye on bone density. A., Christiansen, S. C., Romundstad, P., Cannegieter, S. C., Rosendaal, F. R., and Hammerstrom, J. 2008;9:165. 2011;(7):CD003347. View abstract. Eur Urol 2003;44:519-26. Eur.J.Endocrinol. B., Eriksen, E. F., Ish-Shalom, S., Genant, H. K., Wang, O., and Mitlak, B. H. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. View abstract. Chesnut, C. H., III, Silverman, S., Andriano, K., Genant, H., Gimona, A., Harris, S., Kiel, D., LeBoff, M., Maricic, M., Miller, P., Moniz, C., Peacock, M., Richardson, P., Watts, N., and Baylink, D. A randomized trial of nasal spray salmon calcitonin in postmenopausal women with established osteoporosis: the prevent recurrence of osteoporotic fractures study. 1992;19(3):197-201. The drug name for this radioactive form is Metastron. WebMD does not provide medical advice, diagnosis or treatment. Strontium for Treating Osteoporosis and for Bone Health - WebMD Available at: https://www.guildlink.com.au/gc/ws/servier/pi.cfm?product=sepproto. Bone metastases can be extremely painful. Strontium ranelate may cause unwanted side effects such as stomach pain, diarrhea and headache. Icelandic Red Algae Calcium - Best For Seniors. Bone 2009;45(2):200-206. JAMA 2000;283:1469-75. Hello @bonelady. Henrotin Y, Labasse A, Zheng SX, et al. Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others. View abstract. Strontium is a trace mineral that may aid bone health by reducing bone loss and encouraging bone development. Benefit: Bone & Joint Health. View abstract. The objective of this study was to determine whether strontium citrate can be used to enhance bone healing during MDO in a rabbit model. 1998;4(2):114-119. Strontium absorption also has effects on the absorption ofcalcium, magnesium and phosphate ions. After you stop taking any of these bone-building medications, you generally will need to take another osteoporosis drug to maintain the new bone growth. Rheumatol.Int. View abstract. [4] Simpson, Lani. Medical studies done on the ingredients have shown conclusively that this product is effective.